Autoxidation of the antitumor drug 9-hydroxyellipticine and its derivatives

C Auclair, K Hyland, C Paoletti

Index: Auclair, Christian; Hyland, Keith; Paoletti, Claude Journal of Medicinal Chemistry, 1983 , vol. 26, # 10 p. 1438 - 1444

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Citation Number: 41

Abstract

In aqueous solution and using molecular oxygen as electron acceptor, the antitumor drug 9- hydroxyellipticine (9-OH-E) undergoes a spontaneous oxidation to give hydrogen peroxide (H, O,), the quinone imine 9-oxoellipticine (g-oxo-E), and a dimer of 9-OH-E (9-OH-E2). Electron paramagnetic resonance (EPR) experiments performed either in alkaline MezSO or in phosphate buffer in the presence of the spin trap 5, 5-dimethylpyrroline 1-oxide (DMPO) ...