Tetrahedron letters

Synthesis of a versatile purification handle for use with Boc chemistry solid phase peptide synthesis

LE Canne, RL Winston, SBH Ken

Index: Canne, Lynne E.; Winston, Rachel L.; Kent, Stephen B. H. Tetrahedron Letters, 1997 , vol. 38, # 19 p. 3361 - 3364

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Citation Number: 31

Abstract

The synthesis of a versatile handle for the purification of synthetic peptides is described. The Boc-aminoethylsulfonylethyloxycarbonyl handle is coupled to the NH2-terminus of the resin- bound peptide. Removal of the Boc group affords a free amine which can be derivatized with any of a variety of functionalities. Cleavage from the resin gives a peptide functionalized for covalent chemoselective reaction with the column support. Desired full length peptide is ...