Lactone chemistry. Synthesis of. beta.-substituted,. gamma.-functionalized butan-and butenolides and succinaldehydic acids from glyoxylic acid
JJ Bourguignon, CG Wermuth
Index: Bourguignon, J. J.; Wermuth, C. G. Journal of Organic Chemistry, 1981 , vol. 46, # 24 p. 4889 - 4894
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Citation Number: 62
Abstract
The Mannich-type aminoalkylation reaction of enolizable aldehydes with morpholine and glyoxylic acid instead of formaldehyde was investigated in basic and neutral media were obtained a, y-dimorpholinobutanolides 2 and a-morpholino-y-hydroxybutanolides 1, respectively. In acidic medium the spontaneous elimination of the a-morpholino group afforded the y-hydroxybutenolide 8. The reaction pathways were suggested from the ...
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[UCB, S.A. Patent: WO2005/28435 A1, 2005 ; Location in patent: Page/Page column 8 ;]
[Journal of Organic Chemistry, , vol. 46, # 24 p. 4889 - 4894]