Synthesis, structure–activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-Chloro-N 2-(2- …
TH Marsilje, W Pei, B Chen, W Lu, T Uno…
Index: Journal of Medicinal Chemistry, , vol. 56, # 14 p. 5675 - 5690
Full Text: HTML
Citation Number: 146
Abstract
... Journal of Medicinal Chemistry. ... Multiple pharmaceutical companies have described ALK inhibitors (ALKi) at various stages of development.(16-24) Structures of ALKi in clinical development are depicted in Figure 1. Compound 1 (PF-02341066, crizotinib)(25-28) was ...
Related Articles:
[Sasson, Yoel; Negussie, Samuel; Royz, Michael; Mushkin, Noam Chemical Communications, 1996 , # 3 p. 297 - 298]
Methylhexamethylenetetramine fluoride dihydrate: a new fluorodenitration reagent
[Journal of Fluorine Chemistry, , vol. 78, # 1 p. 91 - 93]