Synthesis and anticancer activity of fluorinated analogues of combretastatin A-4

NJ Lawrence, LA Hepworth, D Rennison…

Index: Lawrence, Nicholas J.; Hepworth, Lucy A.; Rennison, David; McGown, Alan T.; Hadfield, John A. Journal of Fluorine Chemistry, 2003 , vol. 123, # 1 p. 101 - 108

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Citation Number: 67

Abstract

The synthesis of a series of fluorinated benzaldehydes and their use in the Wittig synthesis of fluoro-substituted stilbenes is described. 3, 5-Difluoro-4-hydroxybenzaldehyde (6) and 3- fluoro-4-methoxybenzaldehyde (11) are prepared by Duff formylation of 3, 5-difluorophenol and 2-fluoroanisole, respectively. 2-Methoxy-3, 4-difluorobenzaldehyde was obtained by Friedel–Crafts formylation of 2, 3-difluoroanisole with α, α-dichloromethyl methyl ether. ...