Synthesis of Stereodefined Polysubstituted Olefins. 1. Sequential Intermolecular Reactions Involving Selective, Stepwise Insertion of Pd (0) into Allylic and Vinylic …

…, LR Rogers, F Soleymanzadeh, T Paul

Index: Organ; Cooper; Rogers; Soleymanzadeh; Paul Journal of Organic Chemistry, 2000 , vol. 65, # 23 p. 7959 - 7970

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Citation Number: 67

Abstract

Palladium-catalyzed allylic substitution and cross-coupling reactions have been combined into a sequential procedure to provide a range of disubstituted olefin products starting from two-, three-, and four-carbon common olefin templates. Diverse application of this template strategy is demonstrated in a variety of model studies and in a parallel synthesis (combinatorial) approach to prepare an allylic amine molecular library. An approach ...