Tetrahedron

Ruthenium (II) in ring closing metathesis for the stereoselective preparation of cyclic 1-amino-1-carboxylic acids

K Hammer, K Undheim

Index: Hammer, Kristin; Undheim, Kjell Tetrahedron, 1997 , vol. 53, # 6 p. 2309 - 2322

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Citation Number: 75

Abstract

Stereoselective synthesis of α-amino acids where the α-carbon of the amino acid is incorporated into a five-, six-or seven-membered ring is described. The stereoselective control results from stepwise bisalkenylation of (R)-2, 5-dihydro-3, 6-dimethoxy-2- isopropylpyrazine. Ring closing metathesis was effected by ruthenium (II)-catalysis. The spiro-cycloalkene intermediates were further transformed into 1-aminocycloalkene-1- ...