Development of novel antioxidants: design, synthesis, and reactivity

…, M Flueraru, A Chichirau, LL Chepelev

Index: Hussain, Helmi H.; Babic, Gordana; Durst, Tony; Wright, James S.; Flueraru, Mihaela; Chichirau, Alexandru; Chepelev, Leonid L. Journal of Organic Chemistry, 2003 , vol. 68, # 18 p. 7023 - 7032

Full Text: HTML

Citation Number: 170

Abstract

We are attempting to develop novel synthetic antioxidants aimed at retarding the effects of free-radical induced cell damage. In this paper we discuss the design strategy and report the synthesis of seven novel antioxidants, including six catechols and a benzylic phenol. The bond dissociation enthalpy (BDE) for the most active (weakest) OH bond in each molecule was calculated by theoretical methods, as well as the BDE for the semiquinone radical. ...