Synthesis, Biological Evaluation, and Structure–Activity Relationships of 2-[2-(Benzoylamino) benzoylamino] benzoic Acid Analogues as Inhibitors of Adenovirus …

…, M Strand, EK Andersson, K Edlund…

Index: Oeberg, Christopher T.; Strand, Marten; Andersson, Emma K.; Edlund, Karin; Tran, Nam Phuong Nguyen; Mei, Ya-Fang; Wadell, Goeran; Elofsson, Mikael Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 3170 - 3181

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Citation Number: 10

Abstract

2-[2-Benzoylamino) benzoylamino] benzoic acid (1) was previously identified as a potent and nontoxic antiadenoviral compound (Antimicrob. Agents Chemother. 2010, 54, 3871). Here, the potency of 1 was improved over three generations of compounds. We found that the ortho, ortho substituent pattern and the presence of the carboxylic acid of 1 are favorable for this class of compounds and that the direction of the amide bonds (as in 1) is obligatory ...