Chemical reviews

Rhodium-catalyzed C− C bond formation via heteroatom-directed C− H bond activation

DA Colby, RG Bergman, JA Ellman

Index: Colby, Denise A.; Bergman, Robert G.; Ellman, Jonathan A. Journal of the American Chemical Society, 2008 , vol. 130, # 11 p. 3645 - 3651

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Citation Number: 1914

Abstract

Once considered the “holy grail” of organometallic chemistry, synthetically useful reactions employing CH bond activation have increasingly been developed and applied to natural product and drug synthesis over the past decade. 1 The ubiquity and relatively low cost of hydrocarbons makes CH bond functionalization an attractive alternative to classical CC bond forming reactions such as crosscoupling, which require organohalides and ...