Tetrahedron

Low-valent titanium induced indole formation: syntheses of secofascaplysin, indolopyridocoline and an endothelin-receptor-antagonist

A Fürstner, A Ernst, H Krause, A Ptock

Index: Fuerstner, Alois; Ernst, Andreas; Krause, Helga; Ptock, Arne Tetrahedron, 1996 , vol. 52, # 21 p. 7329 - 7344

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Citation Number: 61

Abstract

The versatility of a titanium-induced reductive oxo-amide coupling reaction is illustrated by the syntheses of the alkaloids secofascaplysin 8 and indolopyridocoline 14 as well as by an efficient and flexible approach to the arylated indole-2-carboxylic acid 4, which has recently been disclosed as a promising endothelin-receptor-antagonist. Depending on the particular substitution pattern in the substrates, either pre-formed titanium on graphite or low-valent ...