(+)-4-Phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist

F Gasparini, W Inderbitzin, E Francotte, G Lecis…

Index: Gasparini, Fabrizio; Inderbitzin, Werner; Francotte, Eric; Lecis, Gabrielle; Richert, Paul; Dragic, Zorica; Kuhn, Rainer; Flor, Peter J. Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 11 p. 1241 - 1244

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Citation Number: 25

Abstract

A new synthesis of (R, S)-PPG (4-phosphonophenylglycine) and the separation of the protected enantiomers leading after deprotection to (+)-and (−)-PPG are described. Pharmacological characterization at the group III metabotropic glutamate receptors hmGluR4a and hmGluR7b revealed (+)-PPG as the active enantiomer.