Novel hybrid molecules based on 15-membered azalide as potential antimalarial agents

…, A Toplak, G Landek, S Alihodžić, E Herreros…

Index: Starcevic, Kristina; Pesic, Dijana; Toplak, Ana; Landek, Goran; Alihodzic, Sulejman; Herreros, Esperanza; Ferrer, Santiago; Spaventi, Radan; Peric, Mihaela European Journal of Medicinal Chemistry, 2012 , vol. 49, p. 365 - 378

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Citation Number: 23

Abstract

Malaria remains the most prevalent tropical disease, and due to the spread of resistant parasites novel therapeutics are urgently needed. Azithromycin has shown potential in malaria treatment so we designed hybrid azalide molecules with the aim to improve activity against and selectivity for the malaria parasite. Novel hybrid molecules comprising 4- aminoquinoline moiety covalently liked to 15-membered azalide scaffold at position C-3′ ...