Tetrahedron

Synthesis of photolabile o-nitroveratryloxycarbonyl (NVOC) protected peptide nucleic acid monomers

ZC Liu, DS Shin, KT Lee, BH Jun, YK Kim, YS Lee

Index: Liu, Zheng-Chun; Shin, Dong-Sik; Lee, Kyu-Teak; Jun, Bong-Hyun; Kim, Yong-Kweon; Lee, Yoon-Sik Tetrahedron, 2005 , vol. 61, # 33 p. 7967 - 7973

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Citation Number: 21

Abstract

The chemical synthesis of peptide nucleic acid (PNA) monomers was accomplished using various combinations of the o-nitroveratryloxycarbonyl (NVOC) group (N-aminoethylglycine backbone) and base labile acyl-type nucleobase protecting groups (anisoyl for adenine and cytosine; isobutyryl for guanine), thus offering a photolithographic solid-phase PNA synthetic strategy compatible with photolithographic oligonucleotide synthesis conditions and ...