Tetrahedron

Novel and efficient Ni-mediated pinacol coupling of carbonyl compounds

L Shi, CA Fan, YQ Tu, M Wang, FM Zhang

Index: Shi, Lei; Fan, Chun-An; Tu, Yong-Qiang; Wang, Min; Zhang, Fu-Min Tetrahedron, 2004 , vol. 60, # 12 p. 2851 - 2855

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Citation Number: 22

Abstract

It was firstly found that the Rieke Ni generated in situ was able to promote the pinacol coupling of various carbonyls efficiently. Based on this information, another catalytically effective, cheaper and more convenient NiCl2 (Cat.)/Mg/TMSCl system was designed and developed further successfully. The interesting single-electron transfer (SET) mechanisms for the coupling reactions were proposed. Additionally, the dl/meso diastereoselectivity ...