Synthesis and trichomonacidal activity of perketals and hydroperoxides
L Cointeaux, JF Berrien, B Camuzat-Dedenis, V Peyrou…
Index: Cointeaux; Berrien; Camuzat-Dedenis; Peyrou; Provot; Bories; Loiseau; Mayrargue Farmaco, 2002 , vol. 57, # 6 p. 457 - 462
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Abstract
Some perketals were synthesized by the Dussault procedure using simple bromides and 2- methoxyprop-2-yl hydroperoxide. Treatment with acetic acid gave the corresponding hydroperoxides. Both perketals and hydroperoxides were tested in vitro as trichomonacidal agents. Most of them exhibited very good activities. The most powerful compound was 2- methoxyprop-2-yl hexadec-1-yl peroxide which exhibited an IC50 value of 0.51 μM being ...
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