Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors

RL Walsky, JN Bauman, K Bourcier, G Giddens…

Index: Drug Metabolism and Disposition, , vol. 40, # 5 p. 1051 - 1065

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Citation Number: 61

Abstract

... UGT1A1, -1A3, -1A4, -1A6, -1A9, -2B7, and -2B15 play a significant role in hepatic drug and xenobiotic metabolism (Miners et al ... substrates are available to correlate in vitro-glucuronidation activities of the major UGTs expressed in human liver with those of drugs or new ...