Development of a Mild Procedure for the Addition of Bisulfite to Electrophilic Olefins

F Fini, M Nagabelli, MFA Adamo

Index: Fini, Francesco; Nagabelli, Murali; Adamo, Mauro F. A. Advanced Synthesis and Catalysis, 2010 , vol. 352, # 18 p. 3163 - 3168

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Citation Number: 24

Abstract

The sulfonic acid functionality is also present in some naturally occurring compounds, for example, in 6-gingesulfonic acid, extracted from ginger (Zingiberis Rhizoma) which is used as an anti-ulcer drug.7 Due to the biological activity of sulfonic acids, several multistep syntheses have been reported. For example, Corey prepared chiral sulfonic acids via a synthetic sequence in which acetophenone reduction was the key enantio-determining step.8 Di Bella and co- ...