Total Synthesis of Myxovirescins, 1 Strategy and Construction of the “Southeastern” Part [O (1)–C (14)]

…, G Adam, S Hintermann, A Neidlein

Index: Seebach, Dieter; Maestro, Miguel A.; Sefkow, Michael; Adam, Geo; Hintermann, Samuel; Neidlein, Axel Liebigs Annalen der Chemie, 1994 , # 7 p. 701 - 718

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Citation Number: 18

Abstract

Abstract In this and the following two papers the synthesis of myxovirescins A 1, A 2 and M 2, 28-membered macrocyclic lactam-lactones with antibiotic acitivity, is described. A retrosynthetic analysis of the myxovirescin family of ca. 30 target molecules leads to a strategy which could be applied to approximately half of them by slight variations of the building blocks used (Schemes 1–3 and following paper). The southeastern part of the ...