Efficient Synthesis of Urea Derivatives via a Sequential One-Pot Nucleophilic Addition/Ugi Five-Component Reaction Under Solvent-Free Conditions

…, K Yadollahzadeh, H Tahermansouri…

Index: Azizian, Javad; Yadollahzadeh, Khadijeh; Tahermansouri, Hasan; Khoei, Davood Chobfrosh; Delbari, Akram Sadat Synthetic Communications, 2012 , vol. 42, # 14 p. 2110 - 2120

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Abstract

The synthesis of new biologically active molecules is an important challenge in the development of improved and innovative drugs. Finding a suitable route with fewer reaction steps for the synthesis of pharmaceutical scaffolds is very interesting. It has been well established that urea derivatives have a significant place in modern medicinal chemistry. [ 1–3 View all references ] Because of the broad pharmacological interest in urea derivatives, their synthesis has been of ...