The Journal of organic chemistry

Synthesis of 2-aminoquinoxalines via one-pot cyanide-based sequential reaction under aerobic oxidation conditions

YH Cho, KH Kim, CH Cheon

Index: Cho, Yeon-Ho; Kim, Kyung-Hee; Cheon, Cheol-Hong Journal of Organic Chemistry, 2014 , vol. 79, # 3 p. 901 - 907

Full Text: HTML

Citation Number: 13

Abstract

A highly efficient synthesis of 2-aminoquinoxalines has been developed via the one-pot two- step cyanide-mediated sequential reactions of ortho-phenylenediamines with aldehydes under aerobic oxidation conditions. A variety of substrates, including aliphatic aldehydes bearing acidic α-protons, are applicable to this protocol and afford the desired 2- aminoquinoxalines in high yields.