Tetrahedron

Strategic use of nickel (0)-catalyzed enyne–epoxide reductive coupling toward the synthesis of (−)-cyatha-3, 12-diene

BA Sparling, GL Simpson, TF Jamison

Index: Sparling, Brian A.; Simpson, Graham L.; Jamison, Timothy F. Tetrahedron, 2009 , vol. 65, # 16 p. 3270 - 3280

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Citation Number: 11

Abstract

Various situations are explored in which the nickel (0)-catalyzed enyne–epoxide reductive coupling was utilized to access key intermediates toward the total synthesis of (−)-cyatha-3, 12-diene (1). Enantioenriched 3, 5-dien-1-ols with a variety of functionality were obtained in a straightforward manner from easily accessible 1, 3-enynes and terminal epoxides.