A 10-step, asymmetric synthesis of (S)-camptothecin
DL Comins, MF Baevsky, H Hong
Index: Comins; Baevsky; Hong Journal of the American Chemical Society, 1992 , vol. 114, # 27 p. 10971 - 10972
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Citation Number: 133
Abstract
(S)-Camptothecin (l), a pentacyclic alkaloid isolated from Cumptotheca acuminata by Wall and co-workers in 1966, con-tinues to be one of the most important lead compounds among the anticancer natural products.'A number of promising analogs have been prepared that show improved solubility, low overall toxicity, and impressive in vivo activity against certain solid tumors.* Some of the more active derivatives include 9-aminocamptothecin"(2), 10, l l ...
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