Construction of Highly Substituted Stereodefined Dienes by Cross??Coupling of α??Allenic Acetates

JS Schneekloth, M Pucheault…

Index: Schneekloth Jr., John S.; Pucheault, Mathieu; Crews, Craig M. European Journal of Organic Chemistry, 2007 , # 1 p. 40 - 43

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Citation Number: 3

Abstract

Abstract The assembly of highly substituted dienes remains a challenge for organic chemistry. This work represents a strategyfor the construction of highly substituted 1, 3- dienes by meansof a Tsuji–Trost cross coupling between α-allenic acetates and organozinc reagents. The reaction is high yielding, and installs a trisubstituted olefin with E/Z selectivities up to 95: 5 favoring the (E) product. A cheap, commercially available ...