Inhibition of human acetyl-and butyrylcholinesterase by novel carbamates of (-)-and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine

…, HW Holloway, D Tweedie, A Shafferman…

Index: Luo, Weiming; Yu, Qian-Sheng; Kulkarni, Santosh S.; Parrish, Damon A.; Holloway, Harold W.; Tweedie, David; Shafferman, Avigdor; Lahiri, Debomoy K.; Brossi, Arnold; Greig, Nigel H. Journal of Medicinal Chemistry, 2006 , vol. 49, # 7 p. 2174 - 2185

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Citation Number: 45

Abstract

A new enantiomeric synthesis utilizing classical resolution provided two novel series of optically active inhibitors of cholinesterase:(-)-and (+)-O-carbamoyl phenols of tetrahydrofurobenzofuran and methanobenzodioxepine. An additional two series of (-)-and (+)-O-carbamoyl phenols of pyrroloindole and furoindole were obtained by known procedures, and their anticholinesterase actions were similarly quantified against freshly ...