Biological evaluation of bisbenzaldehydes against four Mycobacterium species

D Cappoen, D Forge, F Vercammen, V Mathys…

Index: Cappoen, Davie; Forge, Delphine; Vercammen, Frank; Mathys, Vanessa; Kiass, Mehdi; Roupie, Virginie; Anthonissen, Roel; Verschaeve, Luc; Vanden Eynde, Jean Jacques; Huygen, Kris European Journal of Medicinal Chemistry, 2013 , vol. 63, p. 731 - 738

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Citation Number: 9

Abstract

A series of bisbenzaldehydes and structurally related analogs, conveniently synthesized via microwave-assisted reactions, were evaluated in vitro against drug susceptible and multi- drug resistant Mycobacterium tuberculosis, against virulent Mycobacterium bovis, against Mycobacterium ulcerans and against two Mycobacterium avium subspecies. Among the 33 substances that were tested, compound 12, ie 4, 4′-[1, 12-dodecanediyl (oxy)] ...