Organoruthenium antagonists of human A3 adenosine receptors

…, MJ Chow, G Venkatesan, VK Kosaraju…

Index: Paira, Priyankar; Chow, Mun Juinn; Venkatesan, Gopalakrishnan; Kosaraju, Vamsi Krishna; Cheong, Siew Lee; Klotz, Karl-Norbert; Ang, Wee Han; Pastorin, Giorgia Chemistry - A European Journal, 2013 , vol. 19, # 25 p. 8321 - 8330

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Citation Number: 11

Abstract

Abstract Human A 3 adenosine receptor (hA 3 AR) is a membrane-bound G protein-coupled receptor implicated in a number of severe pathological conditions, including cancer, in which it acts as a potential therapeutic target. To derive structure–activity relationships on pyrazolo–triazolo–pyrimidine (PTP)-based A 3 AR antagonists, we developed a new class of organometallic inhibitors through replacement of the triazolo moiety with an ...