Synthesis and evaluation of the anti parasitic activity of aromatic nitro compounds

…, AJ Romanha, RJ Alves, EM Souza-Fagundes…

Index: Lopes, Marcela S.; De Souza Pietra, Renata C.C.; Borgati, Tatiane F.; Romeiro, Carla F.D.; Junior, Policarpo A.S.; Romanha, Alvaro J.; Alves, Ricardo J.; Souza-Fagundes, Elaine M.; Fernandes, Ana Paula S.M.; De Oliveira, Renata B. European Journal of Medicinal Chemistry, 2011 , vol. 46, # 11 p. 5443 - 5447

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Citation Number: 12

Abstract

A series of nitroaromatic compounds was synthesized and evaluated as potential antileishmanial and trypanocidal agents. Five compounds exerted significant anti- leishmanial activity in vitro against promastigotes forms of Leishmania (L.) amazonensis, with IC50 in the range of 23–59 μmol L− 1, but none were active against amastigotes intracellular forms of Trypanosoma cruzi. In vitro cytotoxicity on the proliferation of human ...