Preparation of 4, 6-Disubstituted 5-Pyrimidinesulfonamides

…, B Kasum, PL Keep, S Lazzaro, N Osner, N Stewart…

Index: Best, Wayne M.; Fam, Marie-Anne M.; Gregory, Martin J.; Kasum, Bruno; Keep, Philip L.; Lazzaro, Sam; Osner, Nicole; Stewart, Natasha; Thang, San H.; Watson, Keith G. Synthesis, 1998 , # 1 p. 36 - 38

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Abstract

It is well known12 that activated 4-alkoxypyrimidines will undergo reactions such as transalkoxylation, alkaline hydrolysis and aminolysis, though in general fairly harsh conditions such as elevated temperatures are necessary. Trifluoroethoxy is known13 to be a better leaving group than ethoxy and therefore we decided to test the use of compound 5a as the key precursor to a variety of 4, 6-disubstituted 5-pyrimidinesulfonamides. We have ...