Novel metabolically stable and functionally active mimetic of spermidine

…, AR Simonian, J Vepsäläinen, L Alhonen…

Index: Grigorenko; Vepsalainen; Jarvinen; Keinanen; Alhonen; Janne; Khomutov Russian Journal of Bioorganic Chemistry, 2005 , vol. 31, # 2 p. 183 - 188

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Citation Number: 2

Abstract

Abstract Earlier unknown 1, 8-diamino-3-methyl-4-azanonane (γ-MeSpd) was synthesized. The analogue was a substrate of neither spermine/spermidine N 1-acetyltransferase nor spermine synthase, but was capable to support the growth of DU145 cells having depleted polyamine pools. Such a combination of γ-MeSpd properties discloses novel opportunities to study cellular functions of catabolically unstable and easily interconvertible spermine ...