Muscarinic receptor binding profile of para-substituted caramiphen analogs

…, DL DeHaven-Hudkins, JF Stubbins

Index: Hudkins, Robert L.; DeHaven-Hudkins, Diane L.; Stubbins, James F. Journal of Medicinal Chemistry, 1991 , vol. 34, # 10 p. 2984 - 2989

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Citation Number: 14

Abstract

Para-substituted analogues of the antimuscarinic agent caramiphen were synthesized and evaluated for their ability to bind to the M1 and M2 subtypes of the muscarinic receptor. The purpose of the set was to look for a possible relationship in binding affinity or receptor subtype selectivity with aromatic substituent parametera such as Hammett's u or Hansch's II values. It is felt this could be determined initially with only four properly chosen ...