. beta.-Adrenergic blocking agents: substituted phenylalkanolamines. Effect of side-chain length on. beta.-blocking potency in vitro

W Fuhrer, F Ostermayer, M Zimmermann…

Index: Fuhrer; Ostermayer; Zimmermann; Meier; Mueller Journal of Medicinal Chemistry, 1984 , vol. 27, # 7 p. 831 - 836

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Citation Number: 9

Abstract

IV (see Scheme I) propanolamines [oxprenolol (11) propranolol (III), etc.]. Only relatively few examples of arylpropanolamines and arylbutanolamines have been described in the literature and investigated as@-blocking agents. 14 All these compounds are much weaker@-receptor blockers than the corresponding (aryloxy) propanolamines, and it was therefore concluded that in addition to the optimal length of the side-chain, the ether ...