Studies on antitumor agents. VII. Antitumor activities of O-alkoxyalkyl derivatives of 2'-deoxy-5-trifluoromethyluridine.

…, H MATSUMOTO, N UNEMI, M YASUMOTO

Index: Yamashita; Takeda; Matsumoto; Unemi; Yasumoto Chemical and Pharmaceutical Bulletin, 1987 , vol. 35, # 6 p. 2373 - 2381

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Citation Number: 21

Abstract

Various O-alkoxyalkyl derivatives of 2'-deoxy-5-trifluoromethyluridine (F 3 Thd) were synthesized, and the antitumor activities of the compounds against sarcoma 180 were examined by oral administration to mice. Among the formal-type derivatives, 3', 5'-di-O- ethoxymethyl (3), 3', 5'-di-O-benzyloxymethyl (12), 5'-O-benzyloxymethyl (13) and 3'-O- benzyloxymethyl (14) compounds showed high activities, which were six-fold higher than ...