Phenylhomophthalimide-type NOS inhibitors derived from thalidomide

T Noguchi, H Sano, R Shimazawa, A Tanatani…

Index: Noguchi, Tomomi; Sano, Hiroko; Shimazawa, Rumiko; Tanatani, Aya; Miyachi, Hiroyuki; Hashimoto, Yuichi Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 16 p. 4141 - 4145

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Citation Number: 25

Abstract

Thalidomide shows moderate inhibitory activity toward neuronal nitric oxide synthase (nNOS) and inducible NOS (iNOS), but not toward endothelial NOS (eNOS). Structural development studies of thalidomide yielded novel phenylhomophthalimide-type NOS inhibitors with enhanced activity and different subtype selectivity.