Anti-platelet aggregation activity of some pyrazines.

…, H Takahashi, N Miyata, H HIRONO, T NISHIO…

Index: Ohta, Akihiro; Takahashi, Hiromitsu; Miyata, Naoomi; Hirono, Hiroyuki; Nishio, Toyotaka; Uchino, Etsuo; Yamada, Kenji; Aoyagi, Yutaka; Suwabe, Yasushi; Fujitake, Masayuki; Suzuki, Takahiro; Okamoto, Kazuo Biological and Pharmaceutical Bulletin, 1997 , vol. 20, # 10 p. 1076 - 1081

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Citation Number: 21

Abstract

This report describes the anti-platelet aggregation activity of 48 pyrazines. Among alkyl-and arylpyrazines tested, 2, 3-diphenylpyrazines showed the strongest anti-platelet aggregation activity. Then, various substituents were introduced into the phenyl groups, and the 2, 3-bis (p-methoxyphenyl) pyrazine derivatives were consequently found to possess considerably strong inhibitory activity.