Phosphorus-31 NMR studies of the kinetics of bisalkylation by isophosphoramide mustard: comparisons with phosphoramide mustard

…, M Williamson, VL Boyd, SM Ludeman…

Index: Boal, Jila H.; Williamson, Margaret; Boyd, Victoria L.; Ludeman, Susan M.; Egan, William Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1768 - 1773

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Citation Number: 35

Abstract

Cluster plates (48 wells) were infected with 80 focus-forming units of MSV during 90 min. Medium was then replaced by 1 mL of fresh culture medium containing different concentrations of the test compounds. After 6 days of incubation at 37 "C, transfor- mation of the cell cultures was monitored microscopically. Determination of the cytopathic effect of HIV in human T- lymphocyte MT4 cells has been described.u Briefly, MT-4 cells, subcultured 1 day before the start of the ...