S-(3-Chloro-2-oxo-propyl)-O-ethyl xanthate: a linchpin radical coupling agent for the synthesis of heterocyclic and polycyclic compounds

O Bergeot, C Corsi, M El Qacemi…

Index: Bergeot, Olga; Corsi, Camilla; El Qacemi, Myriem; Zard, Samir Z. Organic and Biomolecular Chemistry, 2006 , vol. 4, # 2 p. 278 - 290

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Citation Number: 32

Abstract

We were attracted by the synthetic importance of this functionality and its wide use in the field of medicinal chemistry for the synthesis of biologically active substances. Therefore, we explored the possibility of introducing this motif using the xanthate (dithiocarbonate) radical transfer we have developed recently. 8 In general, α-chloroketones are generated at the stage in the synthesis at which they are needed, since their high reactivity as electrophiles usually precludes ...