Journal für Praktische Chemie

N??Arylsulfonyl??N′??(pyrimidin??4??yl) ureas??synthesis and reaction with dimethyl sulfoxide

F Zeuner, HJ Niclas

Index: Zeuner, F.; Niclas, H.-J. Journal fuer Praktische Chemie (Leipzig), 1989 , vol. 331, # 1 p. 121 - 128

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Abstract

Abstract The N-arylsulfonyl-N′-(pyrimidin-4-yl) ureas (3a–1) were synthesized by reaction of arylsulfonyl isocyanates (1) with 4-amino-2, 6-dialkylpyrimidines (2). Treatment of 3 with alkali or of 1 with an excess of 4-amino-2, 6-dimethylpyrimidine (2a) gave the salts 4a–e. Reaction of the ureas 3a–c with dimethyl sulfoxide at 90 to 120 C afforded N, N′-bis (2, 6- dimethylpyrimidin-4-yl) ureas 8a–c. The reaction is assumed to involve a four-centre ...