Il Farmaco

Congo red analogues as potential anti-prion agents

…, G Cignarella, D Barlocco, M Gervasoni, G Carcassola…

Index: Villa, Stefania; Cignarella, Giorgio; Barlocco, Daniela; Gervasoni, Marco; Carcassola, Gabriella; Giannino, Laura; Mantegazza, Paolo Farmaco, 2003 , vol. 58, # 9 p. 929 - 937

Full Text: HTML

Citation Number: 7

Abstract

'Transmissible Spongiform Encephalopathies'(TSE) are a group of degenerative, progressive and fatal disorders of CNS which affect both humans and animals, characterised by a long incubation time. The pathogenetic mechanism in TSE is the conversion of normal prion protein (PrPsen) to an altered protease resistant isoform (PrPres) that accumulates in amyloid deposits into the brain; therefore, PrPres is the primary target ...