The Journal of Organic Chemistry

Mild, efficient trimethylaluminum-mediated cyclopropanations. An innovative synthesis of the new dehydrogenase inhibitor spiropentaneacetic acid

JM Russo, WA Price

Index: Russo, Jennifer M.; Price, William A. Journal of Organic Chemistry, 1993 , vol. 58, # 13 p. 3589 - 3590

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Citation Number: 29

Abstract

In recent years, in-depth studies have been carried out detailing the irreversible inactivation of general acyl-CoA dehydrogenase enzymes by (methylenecyclopropy1) acetyl CoA (MCPA-CoA, The free carboxylic acid, specifically (R)-(-) MCPA (lb) 3 is the toxic metabolite of hypoglycin-A, an amino acid found in the fruit of the Jamaican ackee tree. Ingestion of the unripe fruit is known to cam Jamaican vomiting sickness, a severe hypoglycemic response ...