Total synthesis of (+)-angelmarin
J Magolan, MJ Coster
Index: Magolan, Jakob; Coster, Mark J. Journal of Organic Chemistry, 2009 , vol. 74, # 14 p. 5083 - 5086
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Citation Number: 29
Abstract
An anti-austerity therapeutic strategy, targeting this metabolic adaptation of cancer cells, was proposed in 2000 by Esumi and co-workers.(2a) Through the development of an assay method for antiausterity activity,(4) several natural products have been identified with preferential cytotoxicity to PANC-1 cells in nutrient-deprived medium while showing no activity in nutrient-sufficient medium.(5) Two of these compounds, kigamicin D(5a) and arctigenin,(5c) were further ...
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