Synthesis of methaprogerol analogs

GV Kryshtal, GM Zhdankina, AG Konoplyannikov…

Index: Kryshtal; Zhdankina; Konoplyannikov; Tartakovsky; Serebryakov; Smirnov; Konoplyannikova; Agaeva; Zlotina Russian Chemical Bulletin, 2012 , vol. 61, # 2 p. 253 - 258 Izv. Akad. Nauk, Ser. Khim., 2012 , vol. 61, # 2 p. 253 - 258

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Abstract

Abstract Novel synthetic approaches towards analogs of methaprogerol, the efficient wound healing drug, were developed. Several hitherto unknown compounds obtained exhibited in vivo activity similar to methaprogerol. 2-(3-Dimethylaminopropyl)-5-methylhex-4-enoic acid enhanced the efficacy of the treatment of diseases of various etiologies and different organ injuries by transplantation of mesenchymal stem cells (MSC) and MSC-derived ...