Synthesis, DNA binding and antitumor evaluation of styelsamine and cystodytin analogues
HKH Fong, BR Copp
Index: Fong, Hugo K.H.; Copp, Brent R. Marine Drugs, 2013 , vol. 11, # 2 p. 274 - 299
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Citation Number: 7
Abstract
Abstract: A series of N-14 sidechain substituted analogues of styelsamine (pyrido [4, 3, 2- mn] acridine) and cystodytin (pyrido [4, 3, 2-mn] acridin-4-one) alkaloids have been prepared and evaluated for their DNA binding affinity and antiproliferative activity towards a panel of human tumor cell lines. Overall it was found that styelsamine analogues were stronger DNA binders, with the natural products styelsamines B and D having particularly ...
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