Heterocyclic quinones VIII. Synthesis and anti-neoplastic evaluation of 7-substituted-1H-pyrrolo [3, 2-c] quinoline-6, 9-diones and 3-substituted-11H-indolo [3, 2-c] …

P Helissey, H Parrot-Lopez, J Renault, S Cros…

Index: Helissey, Philippe; Parrot-Lopez, Helene; Renault, Jean; Cros, Suzanne; Paoletti, Claude European Journal of Medicinal Chemistry, 1987 , vol. 22, p. 277 - 282

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Citation Number: 13

Abstract

Abstract 7-Methoxy-2, 3, 4-trimethyl-1H-pyrrolo [3, 2-c] quinoline-6, 9-dione 13 and 3- methoxy-6-methyl-11H-indolo-[3, 2-c] quinoline-1, 4-diones 15 and 19 were obtained by oxidation of quinolinamines 9, 11 and 12 with Fremy's salt. The synthesis method of amines 9 and 11 consists of creating the pyrrole or indole nucleus according to Fisher's indolic reaction applied to hydrazones 8 and 10. Aromatization of 11 yielded quinolinamine 12. ...