Substituted 1, 3, 4-thiadiazoles with anticonvulsant activity. 4. Amidines

CB Chapleo, PL Myers, ACB Smith…

Index: Chapleo; Myers; Smith; Stillings; Tulloch; Walter Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 7 - 11

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Citation Number: 92

Abstract

Two different structural types of 2-aryl-1, 3, 4-thiadiazole amidines were synthesized and evaluated for anticonvulsant activity. Enhancement of the inherent anticonvulsant activity therein and separation of this activity from the accompanying sedative action of these ...