Synthesis and biological evaluation of alkyl, alkoxy, alkylthio, or amino-substituted 2, 3-dihydro-1, 5-benzothiazepin-4 (5H)-ones

…, T DATE, K OKAMURA, M TAKEDA, H NARITA…

Index: Inoue, Hirozumi; Konda, Mikihiko; Hashiyama, Tomiki; Otsuka, Hisao; Watanabe, Akishige; Gaino, Mitsunori; Takahashi, Kaoru; Date, Tadamasa; Okamura, Kimio; Takeda, Mikio; Narita, Hiroshi; Murata, Sakae; Odawara, Akio; Sasaki, Haruhiko; Nagao, Taku Chemical and Pharmaceutical Bulletin, 1997 , vol. 45, # 6 p. 1008 - 1026

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Citation Number: 22

Abstract

抄録 2, 3-Dihydro-1, 5-benzothiazepin-4 (5H)-ones substituted with an alkyl, alkoxy, alkylthio, hydroxy, or amino group on the fused benzene ring of the 1, 5-benzothiazepine skeleton were synthesized and their vasodilating, antihypertensive, and platelet aggregation- inhibitory activities were investigated.(-)-cis-3-Acetoxy-5-[2-(dimethylamino) ethyl]-2, 3- dihydro-8-methyl-2-(4-methylphenyl)-1, 5-benzothiazepin-4 (5H)-one ((-)-13e) was ...