Design, synthesis, and biological evaluation of novel 4-substituted 1-methyl-1, 2, 3, 6-tetrahydropyridine analogs of MPTP

…, N Naiman, K Castagnoli, N Castagnoli Jr

Index: Zhao; Dalvie; Naiman; Castagnoli; Castagnoli Jr. Journal of Medicinal Chemistry, 1992 , vol. 35, # 23 p. 4473 - 4478

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Citation Number: 31

Abstract

The exceptionally good MAO-B substrate properties of several l-methyl-4-phenyl-l, 2, 3, 6- tetrahydropyridine (MPTP) derivatives have prompted studies to evaluate the corresponding properties of tetrahydropyridines bearing heteroatom-linked groups at (2-4. The 1-methyl-4- phenoxy-l, 2, 3, 6-tetrahydropyridine analog proved to be an excellent MAO-B substrate. Unlike analogs bearing hydrocarbon substituents at C-4, the resulting dihydropyridinium ...