Cationic contrast agents improve quantification of glycosaminoglycan (GAG) content by contrast enhanced CT imaging of cartilage

…, RC Stewart, BD Snyder, MW Grinstaff

Index: Joshi, Neel S.; Bansal, Prashant N.; Stewart, Rachel C.; Snyder, Brian D.; Grinstaff, Mark W. Journal of the American Chemical Society, 2009 , vol. 131, # 37 p. 13234 - 13235

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Citation Number: 54

Abstract

Abstract Minimally invasive and non-destructive methods to quantify glycosaminoglycans (GAGs) in articular cartilage extracellular matrix are of significant interest for the biochemical analysis of cartilage and diagnosis and tracking of osteoarthritis in vivo. Here, we report the use of cationic iodinated contrast agents in comparison to conventional anionic contrast agents for the quantitative monitoring of GAG concentrations with peripheral quantitative ...