Synthesis and anti-herpes virus activity of acyclic 2'-deoxyguanosine analogs related to 9-[(1, 3-dihydroxy-2-propoxy) methyl] guanine

…, DF Smee, TR Matthews, JPH Verheyden

Index: Martin; McGee; Jeffrey; Hobbs; Smee; Matthews; Verheyden Journal of Medicinal Chemistry, 1986 , vol. 29, # 8 p. 1384 - 1389

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Citation Number: 52

Abstract

G= g-BuilnInYl lectivity of these analogues is due in part to the fact that they are appreciably phosphorylated only in virus-infected cells, where a virus-specified thymidine kinase of low substrate specificity converts the nucleoside analogues to monophosphate^.^ The monophosphates are next converted to diphosphates and then to the corresponding nucleoside triphosphates by cellular enzymes. The triphosphates prevent virus replication ...