Lead Diversification 2: Application to P38, gMTP and lead compounds

…, M Bazin, ME Bunnage, A Calabrese, M Cox…

Index: Masood, M. Abid; Bazin, Marc; Bunnage, Mark E.; Calabrese, Andrew; Cox, Mark; Fancy, Sally-Ann; Farrant, Elizabeth; Pearce, David W.; Perez, Manuel; Hitzel, Laure; Peakman, Torren Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 2 p. 1255 - 1262

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Citation Number: 6

Abstract

Lead Diversification is a new technology platform developed at Pfizer for the functionalization of drug molecules using C–H activation. We describe its application to some drug programs such as P38 and gMTP and the development of some new plate based screens including a fluorination screen.